Chemical approaches to study O-GlcNAcylation
نویسندگان
چکیده
منابع مشابه
olecular mechanisms of O-GlcNAcylation
Protein glycosylation with O-linked N-acetylglucosamine (OGlcNAc) is a reversible post-translational modification of serines/threonines on metazoan proteins and occurring with similar time scales, dynamics and stoichiometry as protein phosphorylation. Levels of this modification are regulated by two enzymes—O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase (OGA). Although the biochemistry of th...
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O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification consisting in the addition of a sugar moiety to serine/threonine residues of cytosolic or nuclear proteins. Catalyzed by O-GlcNAc-transferase (OGT) and removed by O-GlcNAcase, this dynamic modification is dependent on environmental glucose concentration. O-GlcNAcylation regulates the activities ...
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ژورنال
عنوان ژورنال: Chem. Soc. Rev.
سال: 2013
ISSN: 0306-0012,1460-4744
DOI: 10.1039/c2cs35412h